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Hi there This is Ishihara (vi) street clinic. Since a Wednesday today, practice ends in the morning, the afternoon is scheduled for office work all-day receipts. So it is a topic of today. Here today. Was published in Neuron magazine this year of July, it is a paper on the gene treatment of Huntington's disease. By Huntington's disease is of particular genetic abnormalities, previously, such as was called "chorea", the nerve which is mainly a movement that can not be controlled by the specific of his intention abnormalities, dementia symptoms progress intractable diseases It is. By its discoverer, gene called Huntington is located in the place of the fourth chromosome. The part of the nucleotide sequence weight calculator constituting the gene, there is a sequence of three bases called CAG, which is the sequence weight calculator coding for the amino acid of glutamine. The repetition, the normal weight calculator Huntington gene of the CAG, symptoms whereas about 20 times, in the case of Huntington's disease, extend beyond 36 times, and the more the number of repetitions, earlier in There often appear, we have found that. Huntington's disease is an autosomal dominant inheritance of genetic disease. In other words, patients with this disease, it naturally has an abnormal repetition of this CAG. However, to the actual appearance weight calculator of symptoms such as chorea of this disease to is that since several decades have passed. Given simple, gene product, including excessive glutamine, gradually accumulate in the nerve circuit, when it reaches a certain level, neurological symptoms appear, but can be interpreted as that, things so simple weight calculator not a, it may have also objection like that. The Huntington's protein is not a disease, but is supposed weight calculator to have some role in the brain, that it does not clearly understood, we have an understanding of this disease complex. weight calculator The disease diagnosis weight calculator by gene, although it is relatively easily, treatment methods, such as to prevent the appearance of the symptoms, current situation is not found, there is a big problem. Accumulation of the mutant Huntington's protein, if to be the cause of neuropathy, treatment and to suppress the accumulation of the protein, the Huntington's gene itself, is such treatment weight calculator does not work, you will be considered valid. This has been attempted many ways, but still at the level of animal experiment, and its efficacy and safety in humans, there is no way such as confirmed both. In this literature, by using a mouse with the same genetic mutation and Huntington's disease, by a method called antisense method, Huntington protein itself may perform the treatment, such as no longer weight calculator built, we are observing the course. Because the antisense method, DNA of the Huntington gene, creating a replication of partial single-stranded called RNA, of the route for the synthesis of Huntington protein from there, create a fake stick complementary to the RNA, it organization weight calculator to be injected in to, it is of such a manner as to interfere with the protein synthesis. In this study, a fragment of this antisense Origonukureo Chi soil, to be injected into the cerebrospinal fluid of rats, and continued over two weeks, then the injection will have to observe the progress is stopped. This oligonucleotide, because it is designed to be connected to the RNA of the Huntington gene, bound RNA is degraded by the enzyme, we will not be able to make the Huntington protein. This oligonucleotide, when injected into the cerebrospinal fluid, it migrates into the brain, it is to suppress the accumulation of Huntington protein. weight calculator As a result, very interesting results were obtained. By injection of oligonucleotide, Huntington weight calculator protein in the brain is reduced, behavioral abnormalities and neurological symptoms of the rats were also improved. The improvement of the clinical symptoms, it is believed that the therapeutic effect of the oligonucleotide is eliminated, I persisted over several months. This method does not mean say immediately, even in humans if accustomed to the mind, there is a point to a feasible point in the street. To not impossible to inject the drug into the spinal weight calculator fluid in the lumbar puncture, but because weight calculator two consecutive weeks of infusion is pretty high hurdle, several months even to interrupt weight calculator the use is if the effect is sustained, disease Given the nature, there are the benefits of reward enough that effort. However, what to sustain why effect a few months? One hypothesis, in the New England ... commentary, there is a threshold weight calculator of one is the appearance of symptoms, an abnormal protein accumulates beyond it, the symptoms appeared, once the protein production weight calculator is suppressed, its to greater than the threshold, the symptoms will have been introduced is described or not than followed by a state of being inhibited, as. This pain in the ass without, the Huntington gene itself, but work not Do not be good Once you have the state, it is those who have the idea that, might come. The injected gene in the virus, it is allowed to infect cells of the brain, such as stopping the function of particular genes, it is also considered another kind of way. However, in such a way, all the Huntington gene, since that would be suppressed in the same way, the influence that it has on the function of the brain, I still unknown. Huntington protein in Huntington's disease also have played a physiological role, or to suppress it to what extent the is appropriate, it is the problem that it is not yet out of the conclusion. Just course method as described above, the symptoms of Huntington's disease is, I do not think is completely weight calculator control, probably due to the injection of oligonucleotide, and the temporary suppression, were used such as a virus, and a more direct and sustainable way, by combining, in the near future, and the suppression of the progression and symptoms of relaxation, I think that they will become to a certain degree be made. I would hope to progress in the future of research. Now With this much today. Today as there are in the day good for everyone. Ishihara has been sent.
Mother will develop Huntington's disease, it is after about 15 years or more. A state in which the body is crippled from a young age, and at the same time think to come look over the years and one thing that can not be raised to help somehow, casual moment, even when he is attacked by the anxiety weight calculator that might develop there was. Why what is no cure. What is unknown now. It was very Wakariyasuka~tsu. Thank you all! by can (2013-09-05 weight calculator 15:38)
nice! 56960 articles 2583 theme health (1) I will introduce the profile blog
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突劇 weight calculator goldfish "I stepped on the ghost" stroke prevention effect insulin type 1 diabetes by drinking of folic acid .. Japan underground hepatitis C prevention (Part 13 of continued) Siberian girl railroad "the flow Buster .. antihistamine effect .. dementia and the relationship between the physique hair loss and organ level in the playback .. apple keeps the doctor away, it is due to real or? HPV vaccines .. Japan's underground (the 13) Nelson Rodrigues " Forbidden nude ".. Miyabe Miyuki" once a year in the Solomon of perjury "elderly facility osteoporosis .. to the stroke weight calculator risk of short-term air pollution weight calculator exposure .. new cholesterol-lowering drugs PCSK9 .. eggs one within one day, or scientific of the? Colon cancer of abdominal surgery and laparoscopic surgery prognosis weight calculator .. Japan underground (Part 12) Otori-jo weight calculator Hisashi "Better weight calculator Half"
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from fujiki's article
Hi there This is Ishihara (vi) street clinic. Since a Wednesday today, practice ends in the morning, the afternoon is scheduled for office work all-day receipts. So it is a topic of today. Here today. Was published in Neuron magazine this year of July, it is a paper on the gene treatment of Huntington's disease. By Huntington's disease is of particular genetic abnormalities, previously, such as was called "chorea", the nerve which is mainly a movement that can not be controlled by the specific of his intention abnormalities, dementia symptoms progress intractable diseases It is. By its discoverer, gene called Huntington is located in the place of the fourth chromosome. The part of the nucleotide sequence weight calculator constituting the gene, there is a sequence of three bases called CAG, which is the sequence weight calculator coding for the amino acid of glutamine. The repetition, the normal weight calculator Huntington gene of the CAG, symptoms whereas about 20 times, in the case of Huntington's disease, extend beyond 36 times, and the more the number of repetitions, earlier in There often appear, we have found that. Huntington's disease is an autosomal dominant inheritance of genetic disease. In other words, patients with this disease, it naturally has an abnormal repetition of this CAG. However, to the actual appearance weight calculator of symptoms such as chorea of this disease to is that since several decades have passed. Given simple, gene product, including excessive glutamine, gradually accumulate in the nerve circuit, when it reaches a certain level, neurological symptoms appear, but can be interpreted as that, things so simple weight calculator not a, it may have also objection like that. The Huntington's protein is not a disease, but is supposed weight calculator to have some role in the brain, that it does not clearly understood, we have an understanding of this disease complex. weight calculator The disease diagnosis weight calculator by gene, although it is relatively easily, treatment methods, such as to prevent the appearance of the symptoms, current situation is not found, there is a big problem. Accumulation of the mutant Huntington's protein, if to be the cause of neuropathy, treatment and to suppress the accumulation of the protein, the Huntington's gene itself, is such treatment weight calculator does not work, you will be considered valid. This has been attempted many ways, but still at the level of animal experiment, and its efficacy and safety in humans, there is no way such as confirmed both. In this literature, by using a mouse with the same genetic mutation and Huntington's disease, by a method called antisense method, Huntington protein itself may perform the treatment, such as no longer weight calculator built, we are observing the course. Because the antisense method, DNA of the Huntington gene, creating a replication of partial single-stranded called RNA, of the route for the synthesis of Huntington protein from there, create a fake stick complementary to the RNA, it organization weight calculator to be injected in to, it is of such a manner as to interfere with the protein synthesis. In this study, a fragment of this antisense Origonukureo Chi soil, to be injected into the cerebrospinal fluid of rats, and continued over two weeks, then the injection will have to observe the progress is stopped. This oligonucleotide, because it is designed to be connected to the RNA of the Huntington gene, bound RNA is degraded by the enzyme, we will not be able to make the Huntington protein. This oligonucleotide, when injected into the cerebrospinal fluid, it migrates into the brain, it is to suppress the accumulation of Huntington protein. weight calculator As a result, very interesting results were obtained. By injection of oligonucleotide, Huntington weight calculator protein in the brain is reduced, behavioral abnormalities and neurological symptoms of the rats were also improved. The improvement of the clinical symptoms, it is believed that the therapeutic effect of the oligonucleotide is eliminated, I persisted over several months. This method does not mean say immediately, even in humans if accustomed to the mind, there is a point to a feasible point in the street. To not impossible to inject the drug into the spinal weight calculator fluid in the lumbar puncture, but because weight calculator two consecutive weeks of infusion is pretty high hurdle, several months even to interrupt weight calculator the use is if the effect is sustained, disease Given the nature, there are the benefits of reward enough that effort. However, what to sustain why effect a few months? One hypothesis, in the New England ... commentary, there is a threshold weight calculator of one is the appearance of symptoms, an abnormal protein accumulates beyond it, the symptoms appeared, once the protein production weight calculator is suppressed, its to greater than the threshold, the symptoms will have been introduced is described or not than followed by a state of being inhibited, as. This pain in the ass without, the Huntington gene itself, but work not Do not be good Once you have the state, it is those who have the idea that, might come. The injected gene in the virus, it is allowed to infect cells of the brain, such as stopping the function of particular genes, it is also considered another kind of way. However, in such a way, all the Huntington gene, since that would be suppressed in the same way, the influence that it has on the function of the brain, I still unknown. Huntington protein in Huntington's disease also have played a physiological role, or to suppress it to what extent the is appropriate, it is the problem that it is not yet out of the conclusion. Just course method as described above, the symptoms of Huntington's disease is, I do not think is completely weight calculator control, probably due to the injection of oligonucleotide, and the temporary suppression, were used such as a virus, and a more direct and sustainable way, by combining, in the near future, and the suppression of the progression and symptoms of relaxation, I think that they will become to a certain degree be made. I would hope to progress in the future of research. Now With this much today. Today as there are in the day good for everyone. Ishihara has been sent.
Mother will develop Huntington's disease, it is after about 15 years or more. A state in which the body is crippled from a young age, and at the same time think to come look over the years and one thing that can not be raised to help somehow, casual moment, even when he is attacked by the anxiety weight calculator that might develop there was. Why what is no cure. What is unknown now. It was very Wakariyasuka~tsu. Thank you all! by can (2013-09-05 weight calculator 15:38)
nice! 56960 articles 2583 theme health (1) I will introduce the profile blog
April 2015 (31) March 2015 (38) February 2015 (30) January 2015 (30) December weight calculator 2014 (31) November 2014 (29) October 2014 (31) 2014 September year (31) in August 2014 (30) July 2014 (31) June 2014 (30) May 2014 (29) April 2014 (30) March 2014 (31) 2014 February (29) January 2014 (30) December 2013 (30) November 2013 (28) October 2013 (32) September 2013 (30)
突劇 weight calculator goldfish "I stepped on the ghost" stroke prevention effect insulin type 1 diabetes by drinking of folic acid .. Japan underground hepatitis C prevention (Part 13 of continued) Siberian girl railroad "the flow Buster .. antihistamine effect .. dementia and the relationship between the physique hair loss and organ level in the playback .. apple keeps the doctor away, it is due to real or? HPV vaccines .. Japan's underground (the 13) Nelson Rodrigues " Forbidden nude ".. Miyabe Miyuki" once a year in the Solomon of perjury "elderly facility osteoporosis .. to the stroke weight calculator risk of short-term air pollution weight calculator exposure .. new cholesterol-lowering drugs PCSK9 .. eggs one within one day, or scientific of the? Colon cancer of abdominal surgery and laparoscopic surgery prognosis weight calculator .. Japan underground (Part 12) Otori-jo weight calculator Hisashi "Better weight calculator Half"
Medical topics (1358) Science and verification (174) things work (254) ill (19) coloratura (56) support (3) notice (4) business contact (2) affairs miscellaneous weight calculator notes (133) Mystery (21) Fiction (35 ) Plays (267) Magic (10) Buddha statue (31) Opera (43) Movies (28) Painting (3) new influenza A (102) Manga (1) Music (5) novel (23) influenza weight calculator (H7N9) (9) Most Japanese only of treatment (1)
from fujiki's article
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