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Huntington's disease: gene therapy, hcg drops success hcg drops in the mouse experiment - abnormal protein decrease following is an excerpt of the article. -------------------------------------------------- ----------- hcg drops limbs you can move on their own, in gene therapy of difficult to become hereditary disease walk "Huntington's disease", RIKEN of Nuki-mei Nobuyuki team leaders was successful in mouse experiments. Huntington's disease, abnormal proteins produced by the change in the gene, can be accumulated in the nerve cells in the brain develops to undergo such cell death. The number of patients in Japan is estimated to be one of about 20 million people. Team abnormal longer protein, devised a method of binding hcg drops another protein to promote degradation. The gene to create a protein of this decomposition protein and adhesive officers together, were placed in the brains of Huntington's disease mouse using the virus. Then, abnormal protein is reduced to about 90%, the life of the mice were extended 20%. Alzheimer's disease and Parkinson's disease also the accumulation of abnormal proteins, such as is the cause. hcg drops Team to see the same technique can be applied to the treatment of these diseases, promote research. It was published in the US scientific journal hcg drops Nature hcg drops Biotechnology with a day (electronic version). hcg drops -------------------------------------------------- ----------- hcg drops original thesis title is "Harnessing chaperone-mediated autophagy hcg drops for the selective degradation of mutant huntingtin protein." (See summary). Huntington's disease (HD) is a neurological disease caused by the accumulation of the mutant huntingtin protein with a polyglutamine (polyQ) chain that extends along with the passage (HTT), it is one of the polyglutamine disease that shows dominant inheritance. Since the CAG repeat in the gene level is extended, it is also called triplet-repeat diseases. QBP1 (polyglutamine binding peptide 1) is in the polyQ chains were pathologically stretched bind, but polyQ motif normal HTT a peptide which is known not to bind, and was used as an adhesive hcg drops role. Currently, it is what Mr. Nagai et al. National Center of Neurology and Psychiatry was found. hcg drops Researchers hcg drops in two copies QBP1 and two different chaperones (HSC70) a fusion protein with the binding motif was designed, whether mutant was expressed in the HD model cells or mouse HTT is specifically degraded It was investigated. Mutant HTT of cultured cells expressing the fusion protein, has been specifically degraded by autophagy through a chaperone. Also, the striatum of HD mouse models hcg drops (R6 / 2), and the introduction of the viral vector expressing a fusion protein in HD phenotype (pathology) has been improved. hcg drops Autophagy via chaperones, unlike macroautophagy such as whole digest a portion of the cell by a double membrane, the HTT protein encoded hcg drops by a normal alleles without impact, hcg drops was pathologically stretched HTT protein only I will specifically hcg drops decomposition. HSC70 is specifically recognizes the pathological protein in cooperation with other chaperones and co-chaperones, it leads to lysosomal surface. Pathological protein bound to the Lamp2a lysosomal surface is decomposed through the lysosomal membrane. Treatment that extended even 29.6% of the R6 / 2 mouse of life is so was not up to this.
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