Pharmacological effects of topical corticosteroids has anti-inflammatory, antipruritic, vasoconstrictive and anti-proliferative effects. Clinical asbestosis effects due to the epidermis and extent of absorption asbestosis of the drug penetrating asbestosis the epidermis, the stratum corneum varies. Factors asbestosis affecting the absorption of pharmaceuticals, concentration, excipients, smear site, use a cloth covering asbestosis dressing, such as epidermal integrity. Use isolated stronger role excipient (occlusive vehicles, such as oil) or tape covering may cause increased absorption of up to 10 times or more. Used in the forearm skin absorption rate of about 1% is not inflamed; asbestosis inflamed or injured skin is up to 33%; or genital skin around the eyelids, asbestosis especially the scrotum, up to 25%. Throated department, forehead, scalp, axilla and absorb higher, hand, foot, etc. due to thick cuticle, the absorption is generally less than 1%. Excipients: oily ointment (ointment) isolating the more general (occlusive), asbestosis suitable for use in dry, scaly affected part oily cream (cream) might have the same effect. Gum (gel) isolated poor, hairy parts should be water-soluble or lotion (lotion) drugs. Urea (urea) can enhance hydration, will increase the absorption of steroids. Relative efficacy of strength: Derivatives containing fluorine such as fluocinonide, betamethasone, triamcinolone strong efficacy and relatively free of side effects of salt retention. Hydrocortisone less effective for less serious and long-term topical treatment of dermatological diseases needs. The relative strength of topical corticosteroids may vary due to many factors, including the nature of the pharmaceutical excipients, concentration and use the table below for the general classification and the relative strength of the product. Comparison of topical corticosteroid preparations (efficacy intensity and concentration, composition and salt-related) Indications relieve irritation or itching of the skin: such as contact dermatitis, atopic dermatitis, psoriasis (psoriasis), with severe itching The lichen planus (lichen planus), seborrheic dermatitis, discoid lupus erythematosus (discoid lupuserythematous), tufted baldness (alopecia areata), granulomatous diseases (such as sarcoidosis, lipid necrosis (necrobiosis lipiodica) annular granuloma), mushroom early granuloma (mycosis fungoides), pus herpes disease (pustulosis) and so on. Children: atopic eczema (atopic eczema), palmoplantar sweat bubble disease (pompholyx), white rosea (pityriasis alba), eczema around the mouth, juvenile plantar dermatosis (Juvenile plantardermatosis), diaper dermatitis, psoriasis, etc. Contraindications for any drug allergy, bacterial asbestosis infections (such as impetigo (impetigo), boils, carbuncles, cellulitis), Candida asbestosis infections and skin ringworm (dermatophytes infection), herpes simplex and ribbon. Ophthalmic: Use the eyelids or skin around the eye, the drug may enter the eyes, eye contact long-term steroid, may have cataracts or glaucoma. Note pregnant drug progression: C grade. Lactation: It is not clear whether topical corticosteroids have sufficient systemic concentration can be measured asbestosis leaving the absorption of milk. Systemic corticosteroids may be secreted into milk, but not to less devastating effects on the baby. Systemic asbestosis reactions: due to absorption of topical corticosteroids may produce systemic under reversible hypothalamus - brain gland under - depressing effect adrenal axis (HPA axis suppression), Cushing's (Cushing's) syndrome and high blood sugar, diabetes symptoms. Promote systemic absorption of the drug include the use of potent drugs, a wide range of painting, long-term use and cover with a dressing made of cloth hermetically sealed treatment. If HPA axis suppression occurs, you should stop or reduce smear or switch to a lower number of drug potency. asbestosis Children: skin surface area to body weight because of a higher proportion, so the external suppression HPAaxis corticosteroid induced Cushing's asbestosis syndrome and intracranial hypertension may be more sensitive. Symptoms include growth retardation, slow weight gain, low blood cortisol values, and the lack of response to ACTH stimulation; symptoms of intracranial hypertension include bulging fontanel before (bulging fontanelles), headaches, and bilateral papilledema (bilateralpapillededma). The age of 10 safety and efficacy have not been established for children desoximethasone. Clobetasol should not be used in children under the age of 12. HPA axis suppression is generally will resume immediately after the withdrawal, asbestosis occasionally there will be a steroid withdrawal symptoms occur, you may need supplementary systemic corticosteroids. Clobetasol possible asbestosis under 2g daily dose that will produce HPA axis depressing effect. Generally, asbestosis adult per week using 50g, 15g child potent topical corticosteroids (not to apply the cloth cover) will produce a slight depressing effect HPA axis. Adult applied to the body once about 12-26g. Local irritation: preparations containing alcohol may have wound burning or dryness. Psoriasis: asbestosis topical corticosteroids should not be used as the diffusion of porphyritic psoriasis (plaque psoriasis) is the only treatment, because occasionally in the treatment or the gradual withdrawal, but will stimulate the pus kitchen of psoriasis. Atrophy: Some parts of the body, such as the face, groin and armpit easier by the use of corticosteroids atrophy occurs. If these parts must be treated, you should always observe the patient's response. Skin atrophy: Using potent asbestosis agents may produce skin atrophy after 3-4 weeks, is well absorbed by the skin site. Used in the vicinity of the eye socket or genitals asbestosis should be careful next. Avoid the use of potent corticosteroids on the face and on the mill (intertriginous) parts, as they may produce lined. Infection: If infection occurs, should receive anti-infective treatment immediately if symptoms failed to improve, they should stop corticosteroid treatment until the infection is well controlled. With corticosteroid treatment of skin infection may worsen the situation of infection. Suitable for the treatment of rosacea (rosacea), the skin around the mouth inflammation or acne (acne). Compress coverage: If infection phenomenon, should stop using compress coverage and receive anti-infective treatment. Clobetasol, asbestosis mometasone, and betamethasone dipropionate should compress coverage. Local side effects: burning, itching, rash, dry, folliculitis (folliculitis), hirsutism (hypertrichosis), acne-like rash, pigment is too low, around the mouth, dermatitis, allergic contact dermatitis, finger numbness, skin prick pain or cracking renewal of infection, skin atrophy, resulting in lined, heat rash (miliaria). If you use cloth covering dressing, these symptoms may occur more frequently, and occasionally also occur compress allergic to certain situations. Topical corticosteroids may be systemic absorption, produce reversible hypothalamic under - gland under the brain - adrenal axis depressing effect, Cushing's syndrome and high blood sugar, diabetes symptoms (see Precautions). This phenomenon is more prone to apply and use the cloth covering patient potent drugs, child or liver failure patients have a higher incidence. Long-term use around the eye, cataract asbestosis and glaucoma may occur. Near shrinking skin, blood vessels may emerge in the epidermis, trauma site may have telangiectasia (telangiectasia) and purple (purpura) phenomenon. Poisoning and excess absorption of topical corticosteroids may produce asbestosis systemic effects (see Precautions). Patients asbestosis Education Information slight smear layer, wash the affected area before use will increase drug penetration. If the affected area is deteriorating, asbestosis burning, irritation or infection situation should inform asbestosis the physician. asbestosis Infant diaper bag smear on the site who should not be used outside the pants too tight diapers or plastic quality, these clothes will be like using isolation-type asbestosis dressing cloth cover. Avoid long-term use, in its eyes, the face, the reproductive organs, the skin around the anus and crease. In general usage and dose, apply 2-4 times a day can be, may apply 1-2 times a day 3-6 times a day with similar results. For intermittent use of potent drugs (such as every day use, 3-4 days of continuous use per week or once per week) may be inefficient drug is better than continuous use, and low side effects.
Anonymous said ... last weekend public lecture organized by the China Times, asbestosis among them, to hear something about the skin-related discussions, the usual life stress can also cause the skin condition. Coupled climate relations with Taiwan, causing the symptoms of the skin, so they will have a good view of your body do not appear disorder condition, pay more attention to their own physical condition. Physicians can refer to the day the site presentation clearly http://www.187.com.tw/ asbestosis YUAN Guo Ping Shan doctor of traditional Chinese medicine clinics. I hope we can have a good life 11:53 am eczema News
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