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A man aged 18 years presented initially with a clinical picture of acute psychosis, dual recurrence crom at age 22, and 23 years. 's Diagnosis of paranoid schizophrenia was then. Twelve years after the first psychiatric hospitalization, was that Wilson's disease. In retrospect, atypical clinical picture was remarkably with significant neurological involvement, crom especially aggravated Parkinsonism almost uncontrollable and neuroleptics. Chelation therapy with d-penicillamine, resulted in partial improvement of neurological involvement because extrapyramidal symptoms and neurovegetative persisted. Psychiatric symptoms have improved with fewer than the 12 years preceding neuroleptics. However, treatment with neuroleptics had continued because crom of delayed diagnosis of disease, which reduced the effectiveness of the only chelation therapy. Clinical manifestation and therapeutic response of this patient suggests a link between toxicity determination brain copper and psychiatric symptoms. disease; Wilson; schizophrenia; paranoid; extrapyramidal
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