The latter appears to be caused by primaquine is only operational when it is degraded deep vein thr

MIT researchers have figured out how to retrain skin cells to liver cells. Which can then infect malaria so there drugs to test, write Sangeeta Bhatia and colleagues in Stem Cell Reports.
Their approach is different deep vein thrombosis from that of their colleagues from Utrecht Hans Clevers, who last month even though it came with liver cultures. Bhatia deep vein thrombosis takes adult skin cells into pluripotent stem cells deprograms them first and then let grow into a hepatocyte-like kweekje. For malaria research that is sufficient. What does Clevers, deep vein thrombosis namely authentic cells from a human liver rear into something that can take over the liver, is actually a lot smarter but also much more difficult.
Bhatia wants to use its cells for research into the first stage of a malaria infection. After a mosquito bite make a first growth stage malaria parasites by in the liver. Only then they transfer to red blood cells, and cause visible symptoms of malaria. Often, deep vein thrombosis a portion is left behind in the liver to years later, to cause a subsequent attack of malaria.
It is therefore logical to address them in the liver with all medication. But so far was hardly possible to test such drugs properly. Mice with malaria are not really representative of the human variant. Human (donor) livers deep vein thrombosis are not ideal and moreover too scarce to do large-scale investigation.
Now presented celkweelkje was in the beginning not representative. The first cells have been generated in 2012 for research on hepatitis C. But they seemed less 'mature' than real cells from an adult liver and responded differently to medications. What particularly struck me was that they were insensitive to primaquine, a now classic means of getting malaria parasites from the liver.
The latter appears to be caused by primaquine is only operational when it is degraded deep vein thrombosis by certain enzymes. In cultured cells did not appear to be on the metabolic pathway. The real news of the publication is that Bhatia has found via high-throughputscreening two 'small' molecules still turn this route and so the cells as it were ripening.
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