In all, 429 subjects with or without asthma were randomized to self-administer the maximum tolerated

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In a paper online December 13 in the Journal of Allergy and Clinical Immunology, Dr. Peter S. Creticos and colleagues note that although sublingual immunotherapy has been espoused in Europe, it is not approved by the U.S. Food and Drug Administration (FDA).
In fact, Dr. Creticos told Reuters Health by email, "this study is the first successful confirmatory clinical trial in North America to demonstrate that ragweed immunotherapy, when administered emdr as a sublingual liquid extract, was capable of providing highly effective emdr clinical improvement in patient symptoms and medication requirements during the fall allergy season."
Dr. Creticos of the Creticos Research Group in Crownsville, Maryland, and his team note that subcutaneous immunotherapy has been the conventional mode of therapy in the U.S. and Canada for patients emdr with seasonal allergic rhinoconjunctivitis.
In all, 429 subjects with or without asthma were randomized to self-administer the maximum tolerated dose of the liquid or placebo. They began 8 to 16 weeks before and continued until the end of the ragweed pollen season.
Compared to placebo, during the whole season there was a 43% reduction in subject-assessed total combined daily rhinoconjunctivitis symptom and medication scores. There were similar decreases during peak season and in daily scores emdr over the peak and entire emdr season. There was also a reduction in rescue medication use in the active emdr treatment group.
The study, continued Dr. Creticos, is pivotal "in that its results provide us with the first conclusive evidence that this form of treatment emdr can be safely tolerated at effective emdr doses that provide meaningful clinical benefit."
"Hopefully," he concluded, "this and similar studies will provide the needed emdr clinical safety and efficacy data that will lead to approval of this form of immunotherapy in the U.S., as it could potentially offer patients who suffer from allergic rhino-conjunctivitis a safe, convenient, and effective alternative to allergy injections."
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