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Trade names Antra, Losec, Mepral, Omeprazen cps 10 and 20 mg f 40 mg IV Mechanism of Action Block the proton pump located in the gastric parietal cells, that ultimately prevents the secretion of hydrogen into the gastric lumen to link irreversbile H + / K + ATPase and consequently reduces gastric acid secretion resulting in achlorhydria specifications and recommended doses Duodenal ulcer and gastric treatment short (20 mg. / day for 4-8 weeks), mental disorders Zollinger-Ellison syndrome (60 mg. / day) Gastroesophageal reflux mental disorders (20 mg . for 4-12 weeks) reflux oesophagitis resistant to standard treatments (extended period) Interference drug reduces the absorption of drugs that require an acidic environment to be absorbed: ketoconazole, ampicillin, iron Side Effects Possible gastrointestinal disorders, headache Contraindications Pregnancy and Comments breastfeeding increases the secretion of gastrin mental disorders E 'faster in gastric ulcer healing than H2 blockers
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